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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Platycladus orientalis

Toxicity for Cacumen Platycladi has not been documented in dogs and cats when administered orally in therapeutic
TOXICOLOGY in ruminants including bovine, caprine and ovine (Chizzola et al., 2004). Intraperitoneal LD for Cacumen
doses. Ingestion of Platycladus orientalis has been associated with clinical signs of gastroenteritis and seizures
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Platycladi is 15.2 g/kg of body weight in mice. No deaths were recorded among mice within 72 hours of being
given 60 g/kg of body weight of a decoction of Cacumen Platycladi via intragastric administration (Li, 2002).

Equivalent toxic dose in 20 kg dog: 304 g IP of Cacumen Platycladi decoction.
Equivalent toxic dose in 5 kg cat: 76 g IP of Cacumen Platycladi decoction.

DRUG Validated interactions studies do not exist for Cacumen Platycladi preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported.

Ziziphus jujuba [Ziziphus spinosa] (Chinese Jujube)

Semen Ziziphi Spinosae has been used extensively for the treatment of insomnia. In an animal study,
spinosin a major constituent of Semen Ziziphi Spinosae, dose-dependently augmented pentobarbital
induced sleep, reflected by increased sleep time and reduced sleep latency assessed with the loss-of-
righting reflex (Wang et al., 2008). Various tests on animals including dogs and cats were carried out to
assess the sedative and hypnotic effects of Semen Ziziphi Spinosae and the results showed sedative
effects and synergistic effects with other sedatives and hypnotics (Chang & But, 1987). It has also been
found that Semen Ziziphi Spinosae possessed anxiolytic effects at a lower dose and sedative effects
at a higher dose (Wen et al., 2000). In a human study, Semen Ziziphi Spinosae showed a significant
improvement in sleep quality and well-being without side effects (Bone, 2001).

Toxicity for Semen Ziziphi Spinosae has not been documented in dogs and cats when administered orally in
therapeutic doses. In laboratory animals a single oral dose of 50 g/kg of body weight of Semen Ziziphi Spinosae
TOXICOLOGY (Dharmananda, 2001). Intraperitoneal LD of Semen Ziziphi Spinosae decoction is 14.3 ± 2.0 g/kg of body weight
did not produce any toxic symptoms, and a daily dose of 20 g/kg of body weight for 30 days had no toxic reactions
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in mice (Chang & But, 1987).

Equivalent toxic dose in 20 kg dog: 286 g IP of Semen Ziziphi Spinosae decoction.
Equivalent toxic dose in 5 kg cat: 71.5 g IP of Semen Ziziphi Spinosae decoction.

DRUG Validated interactions studies do not exist for Semen Ziziphi Spinosae preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported. However, Semen Ziziphi Spinosae has
sedative and hypnotic effects. It potentiates the sedative effects of barbiturates (Chen & Chen,
2004).

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