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TM/MC TM/MC
SAFETY INFORMATION

PRECAUTIONS • An examination from a veterinarian is recommended prior to using this product.
• Safe use in pregnant animals or animals intended for breeding has not been proven.
• If animal’s condition worsens or does not improve, stop product administration and
consult your veterinarian.
• Not recommended in canine and feline autoimmune diseases.
• Consult your veterinarian for potential drug interactions.
• Off-label use of this product in ruminants is not recommended.
• Oral use only.

• Administer during or after the animal has eaten to reduce incidence of
gastrointestinal upset.
• Shake well before use.

WARNINGS • To be used in dogs and cats only.
• There is a potential risk of foreign body reactions to injectable hyaluronic acid
(Edwards & Fantasia, 2007).
• Keep out of the reach of children and animals.
• In case of accidental overdose, contact a health professional immediately.

ADVERSE REACTIONS • In humans there have been reports of a transient rise in intra-ocular pressure following
the administration of sodium hyaluronate into the eye. There have also been occasional
reports of hypersensitivity (Martindale, 1996).

• Crystalline deposits on intra-ocular lenses have been reported in human patients following
the use of a high viscosity sodium hyaluronate preparation during cataract surgery
(Martindale, 1996).

• Hyaluronic acid injection related side effects are more common, consisting of erythema,
swelling, pain, itching, discoloration and tenderness at the implant site. Resolution is
spontaneous within one or two days. Hyaluronic acid substance related adverse effects are
rare, less than 1 in 2,000 treatments (Vedamurthy, 2004).

CONTRAINDICATIONS • Injectable hyaluronic acid is contraindicated in active infection of the joint or skin near
the joint (Vedamurthy, 2004; Alam & Pongprutthipan, 2010).
• Contraindicated in autoimmune disease (Alam & Pongprutthipan, 2010).
• Contraindicated in known hypersensitivity to hyaluronic acid
(Alam & Pongprutthipan, 2010).

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