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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Eleutherococcus senticosus
TOXICOLOGY therapeutic doses. Oral LD of Radix Eleutherococci is 31 g/kg of body weight in mice (Mills & Bone, 2000).
Toxicity for Radix Eleutherococci has not been documented in dogs and cats when administered orally in
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Equivalent toxic dose in 20 kg dog: 620 g PO of Radix Eleutherococci.
Equivalent toxic dose in 5 kg cat: 155 g PO of Radix Eleutherococci.

DRUG Validated interactions studies do not exist for Radix Eleutherococci preparations. However, Radix
INTERACTIONS Eleutherococci may elevate serum digoxin levels (McRae, 1996). Radix Eleutherococci inhibits
metabolism of barbiturates possibly by inhibition of cytochrome P450 2C19. Radix Eleutherococci
increases efficacy of the antibiotics monomycin and kanamycin due to enhanced T-lymphocyte
activity (Brinker, 2001).

Ligustrum lucidum (Chinese Privet)

Fructus Ligustri Lucidi is a widely used herbal medicine for the treatment of a variety of
pathologies (An et al., 2007). Fructus Ligustri Lucidi contains potent immune stimulants which
may provide the rational basis for its therapeutic use as a biological response modifier (Sun et
al., 1983). Fructus Ligustri Lucidi is found to exert antitumor properties by modulating immune
response and by reverting macrophage suppression brought about by tumours (Rittenhouse et
al., 1991) and such effects may be due to an increase in phagocytes and lymphokine-activated
killer cells (Lau et al., 1994). The secoiridoid glucosides in Fructus Ligustri, have shown strong
antioxidant effect against free radical-associated hemolysis of erythrocytes (He et al., 2001).
The hepatoprotective effects of Fructus Ligustri Lucidi are due to the oleanolic acid and are
thought to be mediated by an increase in hepatic glutathione regeneration capacity (Yim et al.,
2001).

TOXICOLOGY Toxicity for Fructus Ligustri Lucidi has not been documented in dogs and cats when administered orally in

therapeutic doses. LD value for Fructus Ligustri Lucidi has not been determined.
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DRUG Validated interactions studies do not exist for Fructus Ligustri Lucidi preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported.

Immunine -VM TM | 7