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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Polygala tenuifolia
TOXICOLOGY Toxicity for Radix Polygalae Tenuifoliae has not been documented in dogs and cats when administered orally in

therapeutic doses. Oral LD of Radix Polygalae Tenuifoliae saponin is 3.95 g/kg of body weight in mice (Yao et
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al., 2010).

Equivalent toxic dose in 20 kg dog: 79 g PO of Radix Polygalae Tenuifoliae saponins.
Equivalent toxic dose in 5 kg cat: 19.75 g PO of Radix Polygalae Tenuifoliae saponins.

DRUG Validated interactions studies do not exist for Radix Polygalae Tenuifoliae preparations.
INTERACTIONS Clinical interactions with other drugs have not been reported. However, Radix Polygalae
Tenuifoliae exhibits diuretic effects and concurrent use with diuretic drugs may lead to
increased elimination of water and/or electrolytes (Chen & Chen, 2004).

Ocimum sanctum (Holy Basil)

In several ancient systems of medicine including Ayurveda, Greek, Roman, Siddha and Unani,
Folium Ocimi Sancti has a vast number of therapeutic applications including asthma and
bronchitis (Gupta et al., 2002). In a study without controls, oral administration of an aqueous
extract of dried Folium Ocimi Sancti to 20 human patients with asthma increased lung vital
capacity and relieved laboured breathing (Sharma, 1983). Dietary supplementation with Folium
Ocimi Sancti oil protects against bacterial colonization of the lungs (Saini et al., 2009).

Toxicity for Folium Ocimi Sancti has not been documented in dogs and cats when administered orally in
therapeutic doses. The LD for fixed oil of Folium Ocimi Sancti was calculated at 42.5 mL/kg of body weight and
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TOXICOLOGY The LD of ethanol extract of Folium Ocimi Sancti in adult mice was found to 4.5 g/kg of body weight oral and
long-term use of oil at 3 mL/kg of body weight does not produce any adverse effects in rats (Singh et al., 2007).
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3.2 g/kg of body weight intraperitoneal (Rahman et al., 2011).

Equivalent toxic dose in 20 kg dog: 90 g PO of Folium Ocimi Sancti ethanol extract.
Equivalent toxic dose in 5 kg cat: 22.5 g PO of Folium Ocimi Sancti ethanol extract.

DRUG Validated interactions studies do not exist for Folium Ocimi Sancti preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported.

6 | Pulmo -VM TM