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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Morus alba (White Mulberry)

Pharmacological studies on Cortex Mori Albae Radicis showed cathartic, analgesic, diuretic,
antitussive, antiedema, sedative, anticonvulsant, and hypotensive actions in animals including
dogs (Yamatake et al., 1976). Cortex Mori Albae Radicis was shown to inhibit the inflammatory
process in lung tissue through suppression of the IkappaB signaling pathway and may prove
helpful in the management of asthma, various allergic disorders, sepsis, or any other condition
associated with pulmonary inflammation (Lee et al., 2009). Cortex Mori Albae Radicis has
demonstrated antioxidant activity (Chang et al., 2011) and immunomodulating effects (Kim
et al., 2000). Kuwanon G isolated from Cortex Mori Albae Radicis has exhibited antibacterial
activity against Streptococcus sobrinus, Streptococcus sanguis, and Porpyromonas gingivalis
by condensation of the cytoplasm and inducing morphological damage to the cell wall (Park et
al., 2003).

Toxicity for Cortex Mori Albae Radicis has not been documented in dogs and cats when administered orally in
TOXICOLOGY LD is 5 g/kg of body weight (Chen & Chen, 2004).
therapeutic doses. Oral LD of Cortex Mori Albae Radicis is 10 g/kg of body weight in mice and intraperitoneal
50
50
Equivalent toxic dose in 20 kg dog: 200 g PO of Cortex Mori Albae Radicis.
50 g PO of Cortex Mori Albae Radicis.
Equivalent toxic dose in 5 kg cat:

DRUG Validated interactions studies do not exist for Cortex Mori Albae Radicis preparations.
INTERACTIONS Clinical interactions with other drugs have not been reported.

8 | Pulmo -VM TM