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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Siraitia grosvenorii [Momordica grosvenori] (Monk Fruit)

In traditional Chinese medicine Fructus Momordicae grosvenorii is used as an expectorant and
antitussive, to treat lung congestion, cough and other respiratory ailments. These therapeutic
benefits are attributed to the unique component of Fructus Momordicae grosvenorii which are
the triterpene glycosides, most importantly mogroside-5 (Dharmananda, 2004). Mogroside-5
has also been reported to be an antioxidant agent that can scavenge reactive oxygen species and
prevent DNA damage (Zhang et al., 2011).

Toxicity for Fructus Momordicae grosvenorii has not been documented in dogs and cats when administered orally
TOXICOLOGY 2011). 50
in therapeutic doses. Oral LD of Fructus Momordicae grosvenorii is >10 g/kg of body weight in mice (Nabors,

Equivalent toxic dose in 20 kg dog: >200 g PO of Fructus Momordicae grosvenorii.
Equivalent toxic dose in 5 kg cat: >50 g PO of Fructus Momordicae grosvenorii.

DRUG Validated interactions studies do not exist for Fructus Momordicae grosvenorii preparations.
INTERACTIONS Clinical interactions with other drugs have not been reported.

Verbascum thapsus (Mullein)

From antiquity Verbascum thapsus has been used as a medicinal herb, it contains diverse
polysaccharides, iroid glycosides, flavonoids, saponins, volatile oils and phenylentanoids.
Verbascoside has anti-inflammatory properties since it reduces the production of superoxide
radicals and consequently reduces the activity of inducible nitric oxide synthase [iNOS]
(Speranza et al., 2010). Flos Verbasci has been used for the treatment of inflammatory diseases,
asthma, spasmodic coughs, and other pulmonary problems. Aqueous extracts of Flos Verbasci
has exhibited antibacterial activity against Klebsiella pneumonia, Staphylococcus aureus,
Staphylococcus epidermidis, and Escherichia coli (Turker & Camper, 2002).

TOXICOLOGY Toxicity for Flos Verbasci has not been documented in dogs and cats when administered orally in therapeutic
doses. Oral LD of ethanol extract of Verbascum thapsus is >400 mg/kg in rats (Murti et al., 2011).
50
Equivalent toxic dose in 20 kg dog: >8000 mg PO of ethanol extract of Verbascum thapsus.
>2000 mg PO of ethanol extract of Verbascum thapsus.
Equivalent toxic dose in 5 kg cat:

DRUG Validated interactions studies do not exist for Flos Verbasci preparations. Clinical interactions
INTERACTIONS with other drugs have not been reported.

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