Page 193 - product-manual

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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Calcium Pantothenate [Vitamin B ] (C H CaN O )
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Pantothenic acid is found throughout living cells in the form of coenzyme A (CoA), a vital
coenzyme in numerous chemical reactions (Tahiliani & Beinlich, 1991). CoA is required for
chemical reactions that generate energy from fat, carbohydrates, and proteins. The synthesis of
essential fats, cholesterol, and steroid hormones requires CoA, as does the synthesis of melatonin
and the neurotransmitter, acetylcholine. Heme requires succinyl-CoA for its synthesis and the
metabolism of a number of drugs and toxins by the liver requires CoA (Brody, 1999). Failure to
grow and histological changes are the main signs of pantothenate deficiency in cats (NRC, 2006).

TOXICOLOGY Toxicity for vitamin B has not been documented in dogs and cats when administered orally in therapeutic

5
doses. Oral LD of calcium pantothenate is 10 g/kg of body weight in mice (Unna & Greslin, 1941)
50

DRUG Validated interactions studies do not exist for calcium pantothenate preparations. Clinical interactions
INTERACTIONS with other drugs have not been reported.

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