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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Ascorbic Acid [Vitamin C] (C H O )
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Vitamin C is required for the synthesis of collagen, an important structural component of blood
vessels, tendons, ligaments, and bone. Vitamin C also plays an important role in the synthesis
of the neurotransmitter, norepinephrine. Vitamin C deficiency can slow healing and increase
susceptibility to disease. In dogs and cats supplementation of vitamin C may be beneficial,
particularly in times of stress. Studies have shown a slight depression in serum vitamin C
concentration in response to some conditions and diseases, and supplementation can increase
serum levels in healthy animals (NRC, 2006).

TOXICOLOGY Toxicity for vitamin C has not been documented in dogs and cats when administered orally in therapeutic doses.

Oral LD for ascorbic acid is 11,900 mg/kg in rat and 3,367 mg/kg of body weight in mice (ACROS, 2008).
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DRUG Estrogen-containing contraceptives and aspirin can lower vitamin C levels in plasma and
INTERACTIONS white blood cells (Basu, 1982). High doses of vitamin C have been found to interfere with
the interpretation of certain laboratory tests such as serum bilirubin, serum creatinine, and
the guaiac assay for occult blood (Hendler & Rorvik, 2001).

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