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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Boron (Sodium Borate)

Boron acts directly or indirectly to influence the composition, structure and strength of bones.
Experiments in animals indicate that boron may influence calcium, phosphorus, magnesium,
and cholecalciferol metabolism. A vitamin D deficiency enhances the need for boron, and boron
normalizes abnormalities associated with a magnesium deficiency. Boron also has an effect on
brain electrical activity (Groff et al., 1995; NRC, 2006). The signs of boron deficiency in animals
include depressed growth and in humans, a low-boron diet is associated with increased urinary
calcium and magnesium excretion and with alteration in steroid hormone metabolism (Groff et
al., 1995).

Toxicity for boron has not been documented in dogs and cats when administered orally in therapeutic
TOXICOLOGY pharmacological effect in adult dogs weighing 8 to 12 kg (NRC, 2005). Oral LD for sodium borate is 4.5 g/kg
doses. A study found that daily doses of 3 g of boric acid, 5 g of borax for 8-10 days had no physiological or
50
of body weight and 4.98 g/kg of body weight in male and female rats respectively (Weir & Fisher, 1999).

DRUG Validated interactions studies do not exist for boron preparations. Clinical interactions with other
INTERACTIONS drugs have not been reported.

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