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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Silicon (Sodium Metasilicate)

Silicon is an essential nutrient that plays a role in the calcification and maturation of bone.
Silicon also appears to be a cofactor in prolyl hydrase activity, which is involved in collagen
synthesis. Signs of silicon deficiency are related mainly to aberrant development of connective
tissue and bone (NRC, 2006).

TOXICOLOGY Toxicity for silicon has not been documented in dogs and cats when administered orally in therapeutic doses. No
significant acute toxicity or mortality has been reported in animals given doses up to 3,000 mg/kg of body weight
per day (NRC, 2005). Oral LD for sodium metasilicate is 1,280 mg/kg of body weight in rats and 2,400 mg/kg
50
in mice (Haneke, 2002).

DRUG Validated interactions studies do not exist for silicon preparations. Clinical interactions with
INTERACTIONS other drugs have not been reported.

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