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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Inositol (C H O )
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Inositol and its isomers function as the basis for a number of signalling and secondary messenger
molecules. They are involved in a number of biological processes, including insulin signal
transduction (Larner, 2002), nerve transmission, intracellular calcium concentration control
(Gerasimenko et al., 2006), metabolism of fats and reducing blood cholesterol (Rapiejko et
al., 1986), cell membrane potential maintenance (Kukuljan et al., 1997), serotonin activity
modulation (Einat et al., 2001), and gene expression, (Shen et al., 2003; Steger et al., 2003). No
deficiencies of inositol have been documented in either dogs or cats (NRC, 2006).

TOXICOLOGY Toxicity for inositol has not been documented in dogs and cats when administered orally in therapeutic doses.

Oral LD for inositol is 10 g/kg of body weight in mice (Sciencelab, 2010b).
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DRUG Validated interactions studies do not exist for inositol preparations. Clinical interactions with other
INTERACTIONS drugs have not been reported.

Lecithin

Lecithin is a generic term to designate any group of yellow-brownish fatty substances occurring
in animal and plant tissues, and in egg yolk, composed of phosphoric acid, choline, fatty acids,
glycerol, glycolipids, triglycerides, and phospholipids. Phosphatidylcholine occurs in all
cellular organisms, being one of the major components of the phospholipid portion of the cell
membrane. Lecithin supplementation decreases hyperlipidemia, influences lipid metabolism,
exhibits hepatoprotective (Lamireau et al., 2007) and immunomodulatory (Miranda et al.,
2008) effects.

TOXICOLOGY Toxicity for lecithin has not been documented in dogs and cats when administered orally in therapeutic doses.

Oral LD for lecithin is >8 ml/kg of body weight in rats (Pfizer, 2009).
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DRUG Validated interactions studies do not exist for lecithin preparations. Clinical interactions with
INTERACTIONS other drugs have not been reported.

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