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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Astragalus membranaceus

Toxicity for Radix Astragali has not been documented in dogs and cats when administered orally in therapeutic
TOXICOLOGY doses. In dogs, Radix Astragali was found to be safe and without any side effects in a subchronic toxicity study.

The safety dosage range was 2.85-19.95 g/kg of body weight (Yu et al., 2007). Intraperitoneal LD of Radix
50
Astragali was 40 g/kg of body weight in mice (Chang & But, 1987).
Equivalent toxic dose in 20 kg dog: 800 g IP of Radix Astragali.
Equivalent toxic dose in 5 kg cat: 200 g IP of Radix Astragali.

DRUG Validated interactions studies do not exist for Radix Astragali preparations. Currently there is no
INTERACTIONS evidence of drug interactions resulting from the effects of Radix Astragali on drug-metabolizing
systems (Stargrove et al., 2008).

Rhodiola rosea (Rose Root)

Radix Rhodiola is known to possess adaptogenic and ergogenic properties (Walker & Robergs,
2006), and has been reported to improve endurance exercise capacity (De Bock et al., 2004), to
enhance antioxidant function, and to promote the utilization of fatty acids (Parisi et al., 2010).
In human studies, Radix Rhodiola supplementation was found to reduce both lactate levels
and skeletal muscle damage (Parisi et al., 2010), increase efficiency of the cardiovascular and
respiration systems and prevent fatigue after exhaustive exercise (Evdokimov, 2009). Radix
Rhodiola extract was found to activate the synthesis of ATP in mitochondria and stimulate
reparative energy processes after intense exercise in experimental studies (Abidov et al. 2003).

TOXICOLOGY Toxicity for Radix Rhodiola has not been documented in dogs and cats when administered orally in therapeutic
doses. Oral LD of Radix Rhodiola is 3,360 mg/kg of body weight in rats (Kurkin & Zapesochnaya, 1985).
50
Equivalent toxic dose in 20 kg dog: 67,200 mg PO of Radix Rhodiola.
16,800 mg PO of Radix Rhodiola.
Equivalent toxic dose in 5 kg cat:

DRUG Validated interactions studies do not exist for Radix Rhodiola preparations. Clinical interactions
INTERACTIONS with other drugs have not been reported. However, Radix Rhodiola inhibits cytochrome P450
3A4 and can affect the intracellular concentration of drugs metabolized by this enzyme. Radix
Rhodiola inhibits P-glycoprotein activity and can interfere with the metabolism of certain drugs
(Hellum et al., 2010).

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