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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS
Piper futokadsura (Kadzura Pepper)
Caulis Piperis Kadsurae is widely used in Chinese herbal medicinal prescriptions for the treatment
of asthma and arthritic conditions (Lin et al., 2006). The neolignans, piperkadsin A, B, C and
futoquinol, isolated from Caulis Piperis Kadsurae exhibits anti-inflammatory activities by inhibiting
nitric oxide production. The anti-inflammatory activities of these compounds are also attributed
to their potent free radical scavenging activity (Lin et al., 2006; Kim et al., 2010). Piperlactam S,
an alkaloid isolated from Caulis Piperis Kadsurae prevented LDL peroxidation and ameliorated
free radical-induced oxidative stress on endothelial cells (Tsai et al., 2003). Kadsuketanone A has
been shown to inhibit the inflammatory mediators such as nitric oxide and prostaglandin E (Kim
2
et al., 2011).
TOXICOLOGY Toxicity for Caulis Piperis Kadsurae has not been documented in dogs and cats when administered orally in
therapeutic doses. The LD value has not been determined for Caulis Piperis Kadsurae.
50
DRUG Validated interactions studies do not exist for Caulis Piperis Kadsurae preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported.
8 | Antitis-VM TM
