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TM/MC TM/MC
PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Gentiana macrophylla

Toxicity for Radix Gentianae Macrophyllae has not been documented in dogs and cats when administered orally
in therapeutic doses. Oral LD for gentianine an active constituent of Radix Gentianae Macrophyllae is 480 mg/
TOXICOLOGY kg of body weight in mice (Chen & Chen, 2004).
50

Equivalent toxic dose in 20 kg dog: 9,600 mg PO of gentianine, an active constituent of

2,400 mg PO of gentianine, an active constituent of
Equivalent toxic dose in 5 kg cat: Radix Gentianae Macrophyllae.
Radix Gentianae Macrophyllae.

DRUG Validated interactions studies do not exist for Radix Gentianae Macrophyllae preparations.
INTERACTIONS Clinical interactions with other drugs have not been reported.

Angelica pubescens (Pubescent Angelica)

Radix Angelicae Pubescentis is a traditional Chinese medicinal herb used to treat arthritis. In
animal models, the active chemical compounds of Angelicae Pubescentis such as columbianadin,
columbianetin acetate, bergapten, umbelliferone, and caffeic acid significantly demonstrated
anti-inflammatory and analgesic activities. Other active constituents such as osthole and
xanthotoxin have exhibited only anti-inflammatory activity and isoimperatorin only demonstrated
analgesic effects (Chen et al., 1995). The active constituent osthole, has been shown to inhibit
inflammatory mediators such as 5-lipoxygenase and cyclooxygenase (Liu et al., 1998).

Toxicity for Radix Angelicae Pubescentis has not been documented in dogs and cats when administered orally in
TOXICOLOGY is 160 mg/kg and 945 mg/kg of body weight respectively in rats (Chen & Chen, 2004).
therapeutic doses. Intramuscular LD for xanthotoxin and bergapten isolated from Radix Angelicae Pubescentis
50

Equivalent toxic dose in 20 kg dog: 3,200 mg IM of xanthotoxin and 18,900 mg IM of bergapten.
Equivalent toxic dose in 5 kg cat:
800 mg IM of xanthotoxin and 4,725 mg IM of bergapten.

DRUG Validated interactions studies do not exist for Radix Angelicae Pubescentis preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported. However, osthole, an active constituent of
Radix Angelicae Pubescentis may increase the effects of sodium nitroprusside in vitro (Teng et
al., 1994).

6 | Antitis-VM TM