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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Notopterygium incisum

Toxicity for Radix Notopterygii has not been documented in dogs and cats when administered orally in
TOXICOLOGY therapeutic doses. No fatalities were observed in mice following oral ingestion of aqueous extract of Radix
Notopterygii at 12 g/kg of body weight. Oral LD for essential oil of Radix Notopterygii is 2.83 g/kg of body
50
weight (Chen & Chen, 2004).

Equivalent toxic dose in 20 kg dog: 56.6 g PO of Radix Notopterygii essential oil.
Equivalent toxic dose in 5 kg cat: 14.15 g PO of Radix Notopterygii essential oil.

DRUG Validated interactions studies do not exist for Radix Notopterygii preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported.

Rehmannia glutinosa (Rehmannia)

Radix Rehmanniae Glutinosae is known in Asia as a traditional herbal medicine with anti-inflammatory
properties (Sung et al., 2011). A number of chemical and pharmacological studies have been
conducted on Radix Rehmanniae Glutinosae and more than 70 compounds including iridoids,
saccharides, amino acids, inorganic ions, as well as other trace elements have been identified.
Studies show that Radix Rehmanniae Glutinosae and its active principles possess wide pharmacological
actions on the immune system, endocrine system, cardiovascular system and the nervous system
(Zhang et al., 2008). Radix Rehmanniae Glutinosae has shown strong scavenging activity against
superoxide radical, hydroxyl radical, hydrogen peroxide, and 2,2-diphenyl-1-picrylhydrazyl
(DPPH) radical (Yu et al., 2006a) and to increase the activity of antioxidant enzymes and the
level of glutathione (Yu et al., 2006b).

Toxicity for Radix Rehmanniae Glutinosae has not been documented in dogs and cats when administered orally
TOXICOLOGY weight in mice (WHO, 2007). 50 >10 g PO of 70% methanol extract of Radix Rehmanniae Glutinosae.
in therapeutic doses. Oral LD for 70% methanol extract of Radix Rehmanniae Glutinosae is >2.0 g/kg of body

Equivalent toxic dose in 20 kg dog: >40 g PO of 70% methanol extract of Radix Rehmanniae Glutinosae.
Equivalent toxic dose in 5 kg cat:

DRUG Validated interactions studies do not exist for Radix Rehmanniae Glutinosae preparations.
INTERACTIONS Clinical interactions with other drugs have not been reported. However, caution should be taken
when used with drugs metabolized by CYP3A4 as Radix Rehmanniae Glutinosae could activate
pregnane X receptor (PXR) signalling pathway and induce CYP3A4 reporter gene (Yu et al.,
2011).

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