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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Moringa oleifera (Drumstick Tree)

Moringa oleifera known as “Miracle Tree”, has an impressive range of medicinal uses with
high nutritional value. Different parts of Moringa oleifera contain a profile of important minerals,
and are a good source of protein, vitamins, beta-Carotene, amino acids and various phenolics. The
leaves, roots, seed, bark, fruit, flowers and immature pods of Moringa oleifera act as cardiac
and circulatory stimulants, possess antitumor, antipyretic, antiepileptic, anti-inflammatory,
antiulcer, antispasmodic, diuretic, antihypertensive, cholesterol lowering, antioxidant,
antidiabetic, hepatoprotective, antibacterial and antifungal activities (Anwar et al., 2007). Phenolic
glucosides isolated from Semen et Radix Moringae have demonstrated anti-inflammatory
activity by inhibiting the production of nitric oxide, tumor necrosis factor-alpha, and
interleukin-2 which may benefit in the management of arthritis (Cheenpracha et al., 2010;
Sashidhara et al., 2009).

Toxicity for Semen et Folium Moringae has not been documented in dogs and cats when administered orally
in therapeutic doses. Acute toxicity studies in rats for Folium Moringae aqueous extract showed no toxicity
TOXICOLOGY hydro-ethanol extract in mice was calculated to be 1,800 mg/kg of body weight administered through gastric
or mortality at 2,000 mg/kg of body weight oral dose (Adedapo et al., 2009). The LD for Semen Moringae
50
intubation (Paliwal et al., 2011).

Equivalent toxic dose in 20 kg dog: 36,000 mg of Semen Moringae hydro-ethanol extract via gastric intubation.
Equivalent toxic dose in 5 kg cat: 9,000 mg of Semen Moringae hydro-ethanol extract via gastric intubation.

DRUG In a pre-clinical study, isolated fractions of Semen Moringae inhibited cytochrome P-450
INTERACTIONS and increased the bioavailability of rifampicin (Pal et al., 2011).

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