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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Schisandra chinensis

Toxicity for Fructus Schisandrae has not been documented in dogs and cats when administered orally in therapeutic
TOXICOLOGY doses. Acute toxicity test showed that ethanol extract of Fructus Schisandrae was relatively non-toxic, with an
oral LD value of 35.63 ± 6.46 g/kg of body weight in mice (Pan et al., 2011).
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Equivalent toxic dose in 20 kg dog: 715 g PO of Fructus Schisandrae ethanol extract.
Equivalent toxic dose in 5 kg cat: 180 g PO of Fructus Schisandrae ethanol extract.

DRUG Validated interactions studies do not exist for Fructus Schisandrae preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported. However, in an animal study, Fructus
Schisandrae extract has been shown to inhibit CYP3A (Lai et al., 2009) and may affect the
intracellular concentration of drugs metabolized by this enzyme.

Lysimachia christinae (Christina Loosestrife)
In experimental studies, the aqueous extract of Herba Lysimachiae has demonstrated potent
hypouricemic effects (Wang et al., 2002). In animal models, orally administered Herba Lysimachiae
extract rendered the urine acidic, promoting the dissolution of stones formed under alkaline
conditions (Zhu, 1998). Quercetin, quercetin 3-O-β-D-glucopyranoside, and kaempferol 3-O-β-
D-glucopyranoside are the major constituents of Herba Lysimachiae that have exhibited free
radical scavenging activity (Huang et al., 2006). Flavonoids and phenolic acids of Herba
Lysimachiae have anti-inflammatory activity (Gu et al., 1988).

TOXICOLOGY Toxicity for Herba Lysimachiae has not been documented in dogs and cats when administered orally in

therapeutic doses. The LD value for Herba Lysimachiae has not been determined.
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DRUG Validated interactions studies do not exist for Herba Lysimachiae preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported.

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