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TM/MC TM/MC
PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS
Omphalia lapidescens (Thunderball Fungus)
Sclerotium Omphaliae Lapidescentis is a traditional Chinese medicinal fungus. Wild sclerotium
have been used in anthelmintic therapy in the treatment of taeniasis, ancylostomiasis, ascariasis
and intestinal parasitosis with abdominal pain (PPRC, 2005). An isolated intracellular neutral
protease from Sclerotium Omphaliae Lapidescentis is the major component for the anthelmintic
effect (Zhao, et al., 1998). This biologically active protease is able to destroy the parasite
proteins and exhibits strong lethal effects on parasites. In vitro anthelmintic tests demonstrated
potent anti-parasitic effects on third stage larvae of Ascaris suum. The protease showed no
toxicity or other side effects in the acute toxicity test (Zhou et al., 2009).
TOXICOLOGY Toxicity for Sclerotium Omphaliae Lapidescentis has not been documented in dogs and cats when administered
orally in therapeutic doses. The LD value for Sclerotium Omphaliae Lapidescentis has not been determined.
50
DRUG Validated interactions studies do not exist for Sclerotium Omphaliae Lapidescentis
INTERACTIONS preparations. Clinical interactions with other drugs have not been reported.
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