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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Cellulase

Cellulase is an enzyme that hydrolyses cellulose to its constituent monosaccharide and
disaccharide units. Cellulase is not produced by dogs and cats, therefore, supplementation
with enzymes that contain cellulose in addition to protease, amylase, and lipase can be more
advantageous to dogs and cats as it liberates nutrients such as zinc, selenium, and linoleic acid
that might be bound by fibre (Messonnier, 2001).

TOXICOLOGY Toxicity for oral therapeutic dose of cellulase in dogs and cats has not been documented. The LD value for

50
cellulase has not been determined.

DRUG Validated interactions studies do not exist for cellulase preparations. Clinical interactions
INTERACTIONS with other drugs have not been reported. However, care should be taken when cellulase is
taken along with time-released drugs consisting of cellulose. The enzyme may dissolve the
capsule prematurely, affecting the sustained release effect.

Sucrase

Sucrase, also called invertase, is present in the intestinal mucosa of animals that catalyze the
hydrolysis of sucrose to the simple sugars glucose and fructose. Sucrase is beneficial in helping
prevent gastrointestinal problems and discomfort. In animals, sucrase activity in the intestine
increases as the need for, and secretion of, lactase decreases with age (Blood et al., 2007).

TOXICOLOGY Toxicity for sucrase has not been documented in dogs and cats when administered orally in therapeutic doses.

The LD value for sucrase has not been determined.
50

DRUG Validated interactions studies do not exist for sucrase preparations. Clinical interactions
INTERACTIONS with other drugs have not been reported.

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