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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

Saccharomyces cerevisiae
TOXICOLOGY Toxicity for Faex Medicinalis has not been documented in dogs and cats when administered orally in therapeutic

doses. Oral LD for Faex Medicinalis in rats is >2 g/kg of body weight (Ramberg et al., 2010).
50
Equivalent toxic dose in 20 kg dog: >40 g PO of Faex Medicinalis.
Equivalent toxic dose in 5 kg cat:
>10 g PO of Faex Medicinalis.

DRUG Validated interactions studies do not exist for Faex Medicinalis preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported. However, Faex Medicinalis contains
tyramine, and, although case reports are lacking, concurrent use of yeast supplements with
Monoamine oxidase inhibitor (MAOI) antidepressant drugs should be avoided (Howland,
2006).

Althaea officinalis (Marshmallow)

Radix Althaeae contains mucilage polysaccharides that are effective stimulators of cell
physiology of epithelial cells which can be the rationale in its traditional use in the treatment of
irritated mucous membranes (Deters et al., 2010). Traditionally Radix Althaeae is used in
gastritis, peptic ulcers, enteritis, and colitis. The mucilage can stimulate phagocytosis and
other immune system activities, increase anti-inflammatory activity, and have hypoglycemic
activity. The mucilage can also have antimicrobial, spasmolytic, anti-secretory, diuretic, and
wound healing effects (Jellin et al., 2002).

TOXICOLOGY Toxicity for Radix Althaeae has not been documented in dogs and cats when administered orally in therapeutic

doses. The LD value for Radix Althaeae Cortex has not been determined.
50

DRUG Validated interactions studies do not exist for Radix Althaeae preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported.

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