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PHARMACOLOGICAL ACTIVITIES - TOXICOLOGY - DRUG INTERACTIONS

TOXICOLOGY Laminaria digitata

Toxicity for Thalli Laminariae has not been documented in dogs and cats when administered orally in therapeutic
doses. The LD value for Thalli Laminariae has not been determined.
50

DRUG Validated interactions studies do not exist for Thalli Laminariae preparations. Clinical
INTERACTIONS interactions with other drugs have not been reported. However, the iodine content of
seaweeds may affect measurement of serum thyrotropin levels (Miyai et al., 2008).

Helianthus tuberosus (Jerusalem Artichoke)

Inulin and oligofructose from Radix Helianthi Tuberosi are considered functional food
ingredients since they affect the physiological and biochemical processes in animals, resulting
in better health and reduction in the risk of many diseases (Kaur & Gupta, 2002). Dogs and
cats have complex and diverse colonic populations, which can be influenced by prebiotics.
Fructooligosaccharide supplementation, for example, increased the number of bifidobacteria in
dog feces in one study, while decreasing concentrations of ammonia and amines (Hussein et al.,
1999). Inulin and fructooligosaccharide supplementation could reduce the malodour of cat and
dog feces and may help prevent disease, such as colorectal cancer (Kays & Nottingham, 2008).
Inclusion of low-level supplementation of inulin or fructooligosaccharide in canine diets is
effective in enhancing nutrient digestion and modifying stool metabolite concentrations (Barry
et al., 2009) and may also contribute to the prevention or mitigation of obesity through its
effects on satiety (Bosch et al., 2009). In healthy cats, inulin and oligofructose added to a
high-protein diet were suggested to reduce postprandial amino acid-induced gluconeogenesis
by substitution with propionate (Verbrugghe et al., 2010).

TOXICOLOGY Toxicity for Radix Helianthi Tuberosi has not been documented in dogs and cats when administered orally in

therapeutic doses. The LD value for Radix Helianthi Tuberosi has not been determined.
50

DRUG Validated interactions studies do not exist for Radix Helianthi Tuberosi preparations.
INTERACTIONS Clinical interactions with other drugs have not been reported.

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